Subject Code: CY7L030	Subject Name: Chemistry of Pharmaceutics	L-T-P: 3-0-0	Credit: 3
Prerequisite(s): Nil
Structure and activity: Relationship between chemical structure and biological activity (SAR). Receptor Site Theory. Approaches to drug design. Antibiotics and antibacterials: (i) Introduction (ii) Antibiotic β-Lactam type - Penicillins, Cephalosporins (iii) Antitubercular – Streptomycin (iv) Broad spectrum antibiotics – Tetracyclines (v) Anticancer - Dactinomycin (Actinomycin D) (vi) Antifungal – polyenes (vii) Antibacterial – Ciprofloxacin, Norfloxacin (viii) Antiviral – Acyclovir; Antimalarials : Chemotherapy of malaria. SAR. Chloroquine, Chloroguanide and Mefloquine; Non-steroidal Anti-inflammatory Drugs: Diclofenac Sodium, Ibuprofen and Netopam; Antihistaminic and antiasthmatic agents: Terfenadine, Cinnarizine, Salbutamol and Beclomethasone dipropionate.
Text/ Reference Books: Burger and Wolff M. E. Medicinal Chemistry and Drug Discovery, John Wile. Pandeya S. S. & Dimmock J. R. Introduction to Drug Design, New Age International. Graham & Patrick. Introduction to Medicinal Chemistry, OUP. Goodman & Gilman. Pharmacological Basis of Therapeutics, McGraw-Hill. Lednicer D. Strategies for Organic Drug Synthesis and Design, John Wiley.