Subject Code: CY7L020	Subject Name: Receptor Pharmacology and Drug Discovery	L-T-P: 3-0-0	Credit: 3
Prerequisite(s): Nil
Basic concepts in molecular pharmacology: Receptor-ligand interaction, Enzymes, agonists, partial agonist, inverse agonists, neutral antagonists and antagonist; potency, intrinsic activity and efficacy, Druggable proteome, Drugs targeting GPCRs, G-protein coupled receptor (GPCR) and biochemical classification of its ligands, Conformational dynamics of GPCRs, Orthosteric and allosteric binding sites, Receptor dimerization, Receptor characterizations: measurement of ligand binding and signaling, Dose response: IC50, LD50, GPCR signaling in endocrine, paracrine, autocrine and synaptic transmissions, GPCRs in homeostasis and diseases, Peptide / protein binding GPCRs, inhibition of signaling and opportunity for drug discovery.
Text/ Reference Books: Siehler S. and Milligan G. Protein-Coupled Receptors: Structure, Signaling, and Physiology, Cambridge University Press. Vauquelin G.  and  Mentzer B. V. G-protein-coupled Receptors: Molecular Pharmacology, Wiley. GilchristA., GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions, Wiley.