Subject Code: CY7L016 Subject Name: Chemical Biology of Receptors L-T-P: 3-0-0 Credit: 3
Prerequisite(s): Nil
Origin of life, tree of life, Building blocks of life, Genome and Proteome, Introduction to the cells, Visualizing cells, Chemistry and organization of cells, Cell membrane, Membrane structure, Membrane proteins, G-protein Coupled Receptors (GPCRs): Occurrence and importance, Receptors in human genome, Classification of GPCRs, Structure of GPCRs, Receptor activation mechanism, Desensitization and recycling, Receptor interacting proteins: G-proteins, beta-arrestins, Signal transduction, Secondary messengers: adenyl cyclases, Phospolipases, Rho proteins, Effect on enzymes, ion channels, and transporters. Brief introduction: GPCRs in human body and role in human physiology, Case studies on GPCRs: Rhodopsin and Visual cascades.
Text/ Reference Books:
  1. Alberts B.; Johnson A.; Lewis J.; Raff M.; Roberts K., and walter P.  Molecular Biology of the   Cell, New York Garland Science.
  2. Nelson D. and Cox M. M.  Lehninger Principles of Biochemistry, W. H. Freeman.
  3. Siehler S. and Milligan G. G Protein-Coupled Receptors: Structure, Signaling, and Physiology,  Cambridge university Press.
  4. Gilchrist A. GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and  New Directions, Wiley.