Subject Code: CY7L001	Subject Name: Biochemistry	L-T-P: 3-0-0	Credit: 3
Prerequisite(s): Nil
Composition, structure and function of biomolecules: Amino acids, Carbohydrates, Lipids, Proteins and Nucleic acids. Stabilizing interactions: Van der Waals, electrostatic, hydrogen bonding, hydrophobic interaction, etc. Principles of biophysical chemistry: pH, buffer, reaction kinetics, thermodynamics, colligative properties. Metabolism and bioenergetics: Generation and utilization of ATP. glycolysis, TCA cycle, pentose phosphate pathway, oxidative phosphorylation, gluconeogenesis, glycogen and fatty acid metabolism. Principles of catalysis: enzymes and enzyme kinetics and inhibition, enzyme regulation, mechanism of enzyme catalysis, isozymes. Vitamins and coenzymes. Fundamental processes: DNA replication, repair and recombination; Transcription, RNA processing and splicing, translation. Immune system: Immune system. Active and passive immunity. Complement system. Antibody structure, function and diversity.T, B and macrophages. T and B cell activation. Major histocompatibilty complex. T cell receptor. Text/ Reference Books: Nelson D. and Cox M. M. Lehninger Principles of Biochemistry, W. H. Freeman. Berg, Tymoczko and Stryer Biochemistry. Voet and Voet, Biochemistry. Lodish et al, Molecular Cell Biology. Alberts et al, Molecular Biology of Cell. Lewin B, Gene IX, Jones Bartlett.