Subject Code: CY5L003 Subject Name:  Concept of Organic Synthesis L-T-P: 3-1-0 Credit: 4
Prerequisite(s): Nil
Sterochemistry:Introduction, optical isomerism and chirality, resolution, conformational analysis, stereoelectronic effect, and stereochemical aspects; Reactive Intermediates: Carbenes, Nitrenes, Radicals, Carbo-cations, ylides, benzyne; Substitution and Elimination reactions; Acid and base concept of organic compounds; Ideal synthesis; fundamentals of retro-synthesis; Functional group transformations, umpolung and protecting groups; Reaction mechanisms: Definition of reaction mechanism, transition state theory, Substituent effects, linear free energy relationships, Hammett equation and related modifications. Basic mechanistic concepts like kinetic vs thermodynamic control, Hammond postulate, Curtin-Hammett principle, isotope effects; Oxidation and Reduction reactions, Chemistry of cyclic and acyclic compounds; Aromaticity and Aromatic electrophilic substitution: Basic definition of aromaticity, Huckels rule, intermediates and orientation, electrophiles, reactivity and selectivity, kinetic isotopic effects;Nitration, halogenation, sulfonation, Friedel-Crafts reaction, protonation; Nucleophilic aromatic substitution.

Text/ Reference Books:
  1. Kalsi P. S. Stereochemistry, conformation and Mechanism, New Age International Pvt. Ltd.
  2. Clayden, Greeves, Warren & Wothers, Organic Chemistry, Oxford University.
  3. Carey  F. A. and Sundberg  R. J.  Advanced Organic Chemistry, Part A and Part B, Springer.
  4. March  J. Advanced Organic Chemistry: Reactions, Mechanisms and Structure, Wiley-India.
  5. Eliel E. L. and Wilen S. H. Stereochemistry of Organic Compounds, John Wiley & Sons.
  6. Smith M. B. Organic Synthesis, McGraw-Hill Science.
  7. Pine H. S. Organic Chemistry, McGraw-Hill.